Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi
نویسندگان
چکیده
منابع مشابه
Streptococcus pyogenes strains associated with invasive and non-invasive infections present possible links with emm types and superantigens
Objective(s): Streptococcus pyogenes, a notorious human pathogen is responsible to cause a wide range of infections varies from superficial common clinical illness to severe and life threatening infections. To our knowledge this is the first report exploring the emm types and superantigen/exotoxin gene profile of S. pyogenes from Pakistan. Materials a...
متن کاملStreptococcus pyogenes SpyCEP Influences Host-Pathogen Interactions during Infection in a Murine Air Pouch Model
Streptococcus pyogenes is a major human pathogen worldwide, responsible for both local and systemic infections. These bacteria express the subtilisin-like protease SpyCEP which cleaves human IL-8 and related chemokines. We show that localization of SpyCEP is growth-phase and strain dependent. Significant shedding was observed only in a strain naturally overexpressing SpyCEP, and shedding was no...
متن کاملProphylactic Immunization against Streptococcus sanguis.
Streptococcus sanguis (the Streptococcus s.b.e. of Loewe), originally identified by White and his coworkers, has, with few exceptions, been isolated only from the blood stream of patients with subacute bacterial endocarditis (White, 1944; White and Niven, 1946; Niven and White, 1946; Loewe et al., 1946; Niven et al., 1946; Washburn et al., 1946). This causative organism has a type specificity a...
متن کاملStreptococcus pyogenes ( Group A Streptococcus )
Group A streptococcus (GAS) is synonymous with Streptococcus pyogenes, the only species within this group of β-hemolytic streptococci. GAS is one of the leading pathogenic bacteria that infects children and adolescents, and is associated with a wide spectrum of infections and disease states. Worldwide, there are estimated to be >600 million cases of GAS pharyngitis (“strep throat”) and >100 mil...
متن کاملLow antibody levels against cell wall-attached proteins of Streptococcus pyogenes predispose for severe invasive disease.
Acute-phase serum samples from 70 patients with group A streptococcal (GAS) invasive disease were analyzed for IgG antibodies against 6 recently characterized GAS virulence factors (SclA, SclB, GRAB, MtsA, EndoS, and IdeS) and SpeB. Antibody levels against the cell wall-attached GAS antigens SclA, SclB, and GRAB were significantly lower in patients with severe invasive disease (streptococcal to...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2009
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2009.06.042